ưεᤰä-Ƕ
ա춿 ˼ ľ
March 25, 1999
ҥȤοưϰ츫Ե§Ǥ롣Ե§ͳ褹Τ 줬ʸΥơޤǤ롣ɮԤΤΤޤơĤǶ ץҲ𤹤롣
ưȤϰοſR-Rֳ(RRI)Τ餮ΤȤǤ뤬 ϰ(SV)(TPR)ʤɤȤȤˡư̮찵Ĵ ƥ̤Ǥ롣оݤϤư̮찵ä˼̴ 찵(SBP)Ǥ롣ΥƥϡŵŪΥեɥХåĴ ¸Ƥ(1)
Figure 1: ư̮찵Ĵƥγǰ(ʸ)
찵ѲǾȿͤˤзϤ𤷤̤ȿ ݤãؿG̤ѲȤƿɷϤ Ū˽äоݤǤ찵ȿǤݤãؿ HȤ롣ãؿϤŪʼΤΤ ˤϤޤ꿼Ƨ߹ޤŬʿإǥ롢㤨мʲ(AR) ǥȤʲݰưʿ(ARMA)ǥꤷǤ Ȥä̵ؤΥˤư줿̤ ̡оݤˤߤ餮ɽ褦ȤΤ ޤˤѤƤˡǤä(?)ʥǥˡ ˴ؤǿθϡ㤨ʸ[7]ʤɤ˾ܤΤǡ Ǥϴƿʤ
⤦ŪΤƧ߹ȡͭ̾DeBoerΥǥ[6] ʤ(2)¿ΤˤƤΥǥȡ
- 찵ưɤμ̡дˡ̮̮ȤδطϡSBP ˴ؤưʿѥǥͿ롣μˤꡢФ Фˤ̴ακۤɽ롣
- ƶαˤRRIޤ뤬ͤventricular filling ˱ƶͿưξ̤롣
- SBPΤϡξ̤Windkesselǥˤ¤ǵޤä DBPȤ¤ˤʤ롣
- ȾθƵ(Resp.)ϡⰵѲ𤷤fillingѲ ˤ찵ˤRRIθƵư⤿餵롣
Figure: DeBoerΥǥ[6](Ʃ֥å)Τθ塣 14SeidelHerzel[19] ˤѡ5ӡ6ɮԤκǶ ̤ˤ롣
ΥǥΤ褤ȤϡŪǤȤ˲äơ1 褦ʶưΥɬפȤʤƤSBP뤤RRIư ФȤˤ롣1Τ褦ʥեɥХåƥΥǥ ơֶưΥΤɤΤפ䤦ȡư ͤǤɸк100 msΥˤʤ[24]Τǡ Τ褦餫ŪϰϤ̮̮㤨ǮŪʴĶΤ餮 ˵뤳ȤϺǤȻפ뤫Ǥ롣ƤDeBoer ΥǥϡưˤߤƵۤƱư10٤ 찵Ʊư[12, 17]ưΥʤ˺Ƹ롣
ǤΥǥϡRRIˤߤ嵭ε§Ūư ƸʤƵۤƱưˤĤƤϿ2Resp.Ȥŷ꼰Ϳ ΤǤ뤫ΤȤǤ뤬10٤ưνиˤĤƤ⡢ 6(5)ޤǤSBPΰưʿѤȤRRIޤΤǤ뤫顢(ǽ 5ʬ㤱м5ʬ⤤Ȥ褦)̣Ȥ 롣ơҥȤΰŻưϰ̤˹Ӱǡä˴¬֤ 㤷Ƥ餮Υѥ礹褦ʥե饯ŪĤȤ ѻ[11, 24](7B)ƸǤʤΤǤ
ǶᡢSeidelHerzel[19]ϡӰ(ʤ츫Ե§) ưǥˤƸ뤿ˡDeBoerΥǥ˲Ѥä DeBoerΥǥȰۤʤϡ
- ȾθƵۤαƶ(Ƶ̮)٥DzäŪ ƶ̵뤷(21)
- ƶˤСФαƶˤĤƤϡθ̤ (DeBoerΤ褦)¤ηǤϤʤѤηǸȤRosenblueth Simeone[16]θŵŪʷ̤ѤޤФν̮ θȾʬˤΤ߸ȤðƳ(22)
- ǸФΥȡ̥ꤵƤ̴˱ƶ ޤǤλ٤ãΤ֤ȿнĤǤΥΥ륨ԥͥե ˽ư֤Ȥ߹碌뤳Ȥˤ줿(23)
- Windkesselǥδ»ϡФĥɾ ץ饤㲼ۤɾʤ(24)
- ƴ狼εῴ椬СФΥȡ̥ꤹ ʳǡDeBoerΡ֡5ޤǤΡפȤ褦Ūʲ֤ ϩγưñ˵ῴϩνֻư٥㤹Ȥ
Ūˤ긽̣Τ벾ȤơΥǥˤ Ѥθ ð֤ȤäΤˤ륫Υ쥷ԤȤΤ [9]͡ǤƤ롣Υǥǥߥ졼 ԤȡƵ̮ΤϤǤResp.ŷ꼰ͿƤ ΤǤΤΡãΤ֤礭Ƥȡ10 RRIưȯ褦[19]ˤȤ̣ϡ 줬ߥåȥؤʬȤƴѻȤȤǡʬ С֤¿ѲäƤ⤽μϤޤѤʤȤ ȤǤ롣ޤƴεῴ椫Хȡ̥ؤ ѲƤȡߥåȥ롢ȡ饹ʬ֤ͤ äƤϥŪưȤˤȤʤӰ襹ڥȥ뤬ѻ (3)
何が卵母細胞が子宮に移動するのに役立つ
Figure 3: ƴεῴ椫Хȡ̥ؤ ѲݤRRIΥڥȥ(夫ȡ饹ߥåȥ롢 ; ʸ[19])
SeidelHerzelʸϡ̤˵§ŪʥꥺǤȤƤSBPRRI μ10ä(Mayer)Ȱ츫Ե§ǥΥͤοưƱ ƥफΥɬפȤȯǽȤ ŪǤ롣3ʤΥڥȥߤȡ˹Ӱ äƤ⡢ºݤΥҥȤοưΥڥȥ(7B)Ȥ̤ۤɱ ȤΰݤϿʤ(ʸ[24]⻲)Ϥʤͳˤ ΤǤ?
ͳΰĤϡDeBoerΥǥˤƤSeidelHerzelΤΤˤƤ⡢ 1ǤãؿHˤդ˼ƤΤΡ ǾãؿG(ñ)ǤȤ롣 Τư̮찵ȿͶ⥤ɷƤƤ⡢ưޤ ¤äƤƥȤߤʤʤȤʤʤ顢ȿ ⥤ɷ褹طʤˡ⤽ⰵƴ侺߰ к˦¸ߤ뤳ȤͤȡȿηΤ β֤Ȥ뤫ɤٸƤɬפʤ褦 פ
ĤϡΥʤηŪǥΤߤǥҥȤοư¿ 뤫ɤȤǤ롣ʣΥƥΤǤ ư̮찵(ȿ)ĴƥȤΤϤޤǤʬƥǤꡢ ʬƥˤȤäƤϥΥͤưǤäƤ⡢ƥΤ ߤа̣Τ餮Ǥ(ǤϤʤ)Ȥä𤬽ʬ ͤ롣ʲǤϡ˥ץ롣
ȤǡɮԤΤޤǤӤǤϡӰ襹ڥȥĥΥ ưȤƤοưΥե饯ʬϡмǤǤѲ [25]Τǡ(mediator)ϼΧзϤǤ뤳ȡ ʤ顢찵[4]Ƶ[8, 21]ưȤƱ ¬Ԥä¤ϡοȤδϢϴǤ뤳ȡ۴ķϤ ư[13, 22][5]ˤäƤ Ѳ뤳Ȥñʤ(̵)ΥǤȤϹͤŤ餤ȡ ʤɤ餫ˤʤäƤ롣ˡȤˤäƤ⿴ư ΥΥʬĴߤ뤳[10]ͤ碌ȡ Τ褦ʿưԵ§ΰüϡ뾲ʤɹ⼡γư ȿǤƤΤǤϤʤȤβ⤬Ω(25)βϡ ̲ǥѤǾ̤͡γư٥ЪΥߤ줿ݤ ưĴ٤뤳ȤˤäơľŪĴ٤뤳ȤǤ ͤ롣
Figure 4: ̲ʳ̤ˤߤǾ(EEG)ſ(EOG)ſR-Rֳ(RRI) Ͽ(̲ʳˤĤƤʸ)
Ǽǯ9̾ˤĤơ֤ο̲Ǿ(EEG)ſ(EOG) RRISBPֻƵ۶(ILV)ʤɤϢ³Ū˵ϿEEGEOGʤɤ ǡȤ˿̲ʳô(Awake)ڿ̲(Light; 12ʳ) ̲(Deep; 34ʳ)REM̲(REM)ʬࡢκݤ ɷϽ̤ưĴ٤Ƥߤ(4)ߤ¤ꡢǾο© Ȥ뿼̲οưλˤϥե饯ʬͭȡ ĹΡ֤ͤ(ѸǤ``waxing and wanning''ʤɤȤ⤤)ߤ줺 (4C)դ̴ȤδϢȤREM̲οư(4D)ϡ οưѥ(4A)ƤȤηǧ롣ޤ δ屿ư夷ơư̮(RRIθ)ѻ뤳Ȥ ߤƤȤ롣
Figure 5: ̲ʳ̤ˤߤſR-Rֳ(RRI)̴찵(SBP) ֻƵ۶(ILV)Υѥڥȥ롣ڥȥ̩٤︡ѥ ɸಽƤ롣
ƿ̲ʳ10ʬʾ³ʬ10ʬ֤RRISBPILVǡ ڤФΥѥڥȥ(5)ưˤĤƤϡ áڿ̲̲̲꤬ʤˤĤΰΥѥ Ū˸§ŪʸƵư(0.20.3 Hz)ʬȤʤͻ 롣REM̲ˤƤϡƤӳôƱͤ˹Ӱ ʬĴƤ뤳Ȥ狼롣SBPΥڥȥϡ̲ ʳˤ餺ƹӰʥΥʬ¸ߤƤ롣ޤ ILVˤĤƤϡ̲٤ξ徺ȤȤ˸ƵۼΤε§徺Ȥ ̤줿ե饯ʬͭȡĹ餮ϤۤȤ ߤʤä
Figure 6: ſR-Rֳ(RRI)̴찵(SBP)ӽֻƵ۶(ILV) ѥե饯ʬγ硣A, L, D, RϤ줾ô ڿ̲̲REM̲ɽͤ9̾ʿ ɸǡ ; P < 0.05 from A and R, ; from A, L, and R, *; from A.
ΤȤŪɽˡȤRRIILVθƵưˤߤ §ŪʬȤԵ§ʥΥʬȤȿΰʬΥɾǤ ƻ벽ڥȥˡ[23]ѤRRISBPILVγƻ ե饯ʬγɾ(6)Τ˿̲٤徺 ˤĤơưʤRRIˤȡĹ餮 Ǥե饯ʬγ礬ͭդ㲼Ƥ뤳Ȥ狼롣 SBPˤĤƤϤΤ褦ʷǧ줺ޤILVϳ §ŪǤ뤬̲٤ξ徺ˤȤʤäƤε§Ȥη̤ 줿
̤ǧγưԤʤȤûΥҥǾγưˤϾطʳư ¸ߤǯǤϤ``ongoing activity''νŦϤ [1]ܸη̤ϡΤ褦Ǿ(ط)ư 뾲ʤɤξưǾ𤷤ľŪˡ뤤ϸƵۥѥ ȤˤꡢǾˤȿͥƥ˥ΥͤĴͿƤ ǽΤȻפ롣⤷ǤȤơ줬 ΤʤΤɤΤ褦ʵǽŪյäƤ뤫ˤĤƤϡߤ ȤǤ롣
白血球とは何か
ˤоݤȤRRIưϡϿ֤10ʬȤȤ⤢ꡢ ȡĹȤäƤ⤻5ʬ٤ưǤäǶǤ ``very-low frequency (VLF) oscillation''ȸƤ֤褦Ǥ뤬[14] ⤽¬֤㤷ƿưΥѥ礹(٤Υ§ ĤȤ)Ȥѻ̤ϡ֡1Ȥ֥ (``ultra-low frequency; ULF''ȤƤФ)줿ΤǤä [11, 18]ULFӰΥѥ㤤ۤɿڹɴԤ¸Ψ 㤯ʤȤBigger[2, 3]ƶƤǯULFӰ ˤ뿴ưεˤĤƤθ椬ˤʤĤĤ(褦˻פ)
ULFӰˤ뿴ưβϤϡñRRIʤФʤʤ ȤŪ¾ˡ1Τ褦Ūñʥƥˡưݵ© ̲ݳäȤäưΥꥺࡢγꥺʤɤǤ Ȥ褦ʴŪƤ롣ޤΩ줫ߤƤ⡢ ˶ᤤư礭ɤꤷ褦ȤСΥۥ륿 ŷפεϿ(2448)ǤԽʬǤ롣
Τ褦ʴ顢ǶɮԤϡȾƳΥѤο Ͽ(120mm߲65mm22mm200g)RRI1 msǡ ¢β®٥ˤľư(BM)1ˡ1֤Ϥ국Ͽ ȤߤԤäƤ7A˵Ͽ ٤ʿư˲äơˤȤʤRRIΰθ ˽ä줾BMáƱƴѻ롣ưݵ© ȿӤܺ٤ˤߤƤƱͤηꡢ︡Ԥꥺư ꥺˤRRIBMѲʬȿǤǡƤ뤳Ȥ 狼롣
Figure 7: (A) 6֤Ϥ뿴ſR-Rֳ(RRI; )ư(BM; )εϿ㡣 (B)10ô֤ʿͤ鹽Υѥڥȥ(ξпɽ пȿ-5ꥺ)︡Ԥ4̾(C)RRIBM (10ʿ)Υҡڥȥο٤夲 ˡ2ʬΥǡ֥եȤȤʤä20Ĥʬ ФνʿѤȤƷƤ(BƱ)
ơULFӰˤѥڥȥǤ뤬Ը[11, 18] Ʊͤ٤ΰͤʥ§Ƥ褦ˤߤ(7B) BMˤĤƤƱͤʷ̤Ǥäпȿ-5Ȥ ꥺμȿ㤤ȿӰǤϥڥȥ̩٤㲼뷹 ߤ롣콵֤ȤϿĹ餤äƤ⡢κĹʬ ٤Ϥ٤οƤ뤳ȤԤΤǡULFӰ ˤ뿴ư٤Υ§ĤȤäƤ⡢Ϥ μ˴ؤΤǤȤǤ롣
̣ȤˡRRIBMξԤΥڥȥҡ (7C)ꥺμȿˤ˹⤤(ۤ1Ǥ) ͽۤ줿ȤǤ뤬пȿ-4.5-4.0(2.88.8) -3.8-3.4(0.71.8)μȿӰǡξԤؤ⤯ʤȤ ߤ줿
η̤ɤΤ褦˲᤹٤¤ǺޤΤǤ롣ǾȤߤ γÿư1.53֤μȤ[15] ͤСư̮©̮ε§줿ΤǤʤ ϤʤʤФʤѥڥȥˤΤ褦ʵ§(ȿð )ߤʤΤǤ롣ʵ§Ȥξпɽ ȱƤޤۤɤΤΤʤ顢ʤ襳ҡ0.5( ľС0.7Ǥ)ФΤǤ롣ä С7AΤ褦ʻϴܼʤꥺμ ǤιĴȤ줿ΤǤȤʤ뤬⤽⤳ϥҡ ĤƤΤߤǤꡢĴȤߤϤΥѥڥȥˤĤƤ Ϥʤˡ7CβпɽǤꡢ줬⤷ĴȤǤ ȡμܼ ȤʤäƤ褦ˤߤ롣⤷Τ褦ʴ̯ʼȿ¤ ˤ٤˥뤵줿RRIBMΥѥڥȥظ¸ߤ ȤȡRRIBMλ
Τ褦ʬޤǤ뤳Ȥˤʤ(WeierstrassؿΤ Ǥ![20])桹ιưư(BM)ˤΤ褦ʷŪե饯 §ƤȤǤ⤤Τ?
ƬˤʤäƤΤǡդǽˤơưĹ 餮ˤϹưꥺ̯ʱƶظ¸ߤ뤫ΤʤȤ (26)äƤ
ܸϡʸʲʳظB(ֹ10480005; 1998ǯ) ĶѤ˴ؤϾ带(ˡܱե; 1997ǯ) ӲʳصģĴ(1996ǯ)ˤԤ줿
(Therapeutic Research, 1999 () )
減量のインターバル運動
- 1
- A. Arieli, A. Sterkin, A. Grinvald, and A. Aertsen. Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses. Science, 273:1868-1871, 1996.
- 2
- J. T. Bigger, Jr., J. L. Fleiss, R. C. Steinman, L. M. Rolnitzky, R. E. Kleiger, and J. N. Rottman. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation, 85:164-171, 1992.
- 3
- J. T. Bigger, Jr., R. C. Steinman, L. M. Rolnitzky, J. L. Fleiss, P. Albrecht, and R. J. Cohen. Power law behavior of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction, and patients with heart transplants. Circulation, 93:2142-2151, 1996.
- 4
- G. C. Butler, Y. Yamamoto, and R. L. Hughson. Fractal nature of short-term systolic BP and HR variability during lower body negative pressure. Am. J. Physiol., 267(Regulatory Integrative Comp. Physiol. 36):R26-R33, 1994.
- 5
- G. C. Butler, Y. Yamamoto, H. C. Xing, D. R. Northey, and R. L. Hughson. Heart rate variability and fractal dimension during orthostatic challenges. J. Appl. Physiol., 75:2602-2612, 1993.
- 6
- R. W. DeBoer, J. M. Karemaker, and J. Strackee. Hemodynamic fluctuation and baroreflex sensitivity in humans: a beat-to-beat model. Am. J. Physiol., 253(Heart Circ. Physiol. 22):H680-H689, 1987.
- 7
- M. Di Rienzo, G. Mancia, G. Parati, A. Pedotti, and A. Zanchetti, editors. Frontiers of Blood Pressure and Heart Rate Analysis. IOS Press, Amsterdam, 1997.
- 8
- J. O. Fortrat, Y. Yamamoto, and R. L. Hughson. Respiratory influences on non-linear dynamics of heart rate variability in humans. Biol. Cybern., 77:1-10, 1997.
- 9
- L. Glass and M. C. Mackey. From Clocks to Chaos. The Rhythms of Life. Princeton University Press, Princeton, 1988.
- 10
- Y. Hoshikawa and Y. Yamamoto. Effects of Stroop color-word conflict test on the autonomic nervous system responses. Am. J. Physiol., 272(Heart Circ. Physiol. 41):H1113-H1121, 1997.
- 11
- M. Kobayashi and T. Musha. 1/f Fluctuation of heartbeat period. IEEE Trans. Biomed. Eng., BME-29:456-457, 1982.
- 12
- A. Malliani, M. Pagani, F. Lombardi, and S. Cerutti. Cardiovascular neural regulation explored in the frequency domain. Circulation, 84:482-492, 1991.
- 13
- Y. Nakamura, Y. Yamamoto, and I. Muraoka. Autonomic control of heart rate during physical exercise and fractal dimension of heart rate variability. J. Appl. Physiol., 74:875-881, 1993.
- 14
- Task Force of the European Society of Cardiology, the North American Society of Pacing, and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation, 93:1043-1065, 1996.
- 15
- M. Okawa, M. Matousek, and I. Petersen. Spontaneous vigilance fluctuations in the daytime. Psychophysiology, 21:207-211, 1994.
- 16
- A. Rosenblueth and F. A.
ưεᤰä-Ƕ
This document was generated using the LaTeX2HTML translator Version 96.1 (Feb 5, 1996) Copyright © 1993, 1994, 1995, 1996, Nikos Drakos, Computer Based Learning Unit, University of Leeds.
The command line arguments were:
latex2html -split 0 jres_11.
The translation was initiated by Yoshiharu Yamamoto on 1999ǯ0325 () 1441ʬ41 JST
- ...
- keywords: modelling, arterial baroreflex, central autonomic regulation, long-term heart rate variability
- ...ľ
- ر ظ
- ...24](7B)ƸǤʤΤǤ
- ޤ1Τ褦ΥưΥեɥХåƥǤ ɽ褦Ȥȡǥμ¬֤˱ƾ夲Ƥʤ ʤʤȤޤ긽ŪǤʤ֤롣
- ...Ѥθ
- DeBoerΥǥˤCO=HR SVBP=TPR COʤɤ롣
- ...פ
- ʸǤϿʤΤ褦ʴ顢ǶɮԤ ϡư̮ͿưΥư̮찵ȿͶɤΤ褦Ĵ ˤĤĴ٤Ƥ롣
- ...[1]ܸη̤ϡΤ褦Ǿ(ط)ư
- ơ֥Υ͡פȵƤΤϡŪΥ ̤äǤ롣
- ...
0 コメント:
コメントを投稿